Consider The Source Previews Exciting Fall Tour With New Video [Watch]

first_imgIn the realms of progressive fusion music, Consider the Source stands alone. The group continues to press forward with new and innovative songwriting, and constant touring has earned them a truly devoted following. Formed in 2004, the band’s fusion of progressive rock, jazz, and Eastern sounds continues to impress, only accentuated by the fact that the band is composed of only three members.This fall, CTS will spend a considerable amount of time on the road throughout the country, hitting a number of venues nationwide to keep the fans movin’ and groovin’. In addition to playing shows with TAUK and Papadosio, Consider the Source has an extensive listing of headlining tour dates on the schedule, so there’s no reason to miss out!In anticipation of these exciting tour dates, the band has shared this unique preview video highlighting their tour dates and exciting live shows. Check out the new video below, exclusively via Live For Live Music.You can see Consider the Source’s tour schedule below, and head to their website for details! You can also find their most recent release, World War Trio (Parts 2 & 3) (2016) via Bandcamp.Consider the Source Fall Tour Dates10/07/2016 The Black Sheep, Colorado Springs, CO10/08/2016 Fox Theatre, Boulder, CO10/09/2016 The Bluebird Theater, Denver , CO10/12/2016 The AMP Room, San Antonio, TX10/13/2016 Last Concert Café, Houston, TX10/14/2016 One-2-One, Austin, TX (with Cream Cheese Accident)10/15/2016 Kiva, San Marcos, TX10/20/2016 Harvest House, Denton, TX10/21/2016 Ryleigh’s, Fayetteville, AR10/22/2016 Lefty’s Live Music, Des Moines, IA10/23/2016 Progtoberfest II, Reggie’s Rock Club, Chicago, IL10/26/2016 The Rabbit Hole, Charlotte, NC10/27/2016 Lincoln Theatre, Raleigh, NC (supporting Papadosio)10/28/2016 9:30 Club, Washington, DC (supporting Papadosio)10/29/2016 The Abbey Bar @ Appalachian Brewing Co., Harrisburg, PA11/03/2016 Pacific Standard Tavern, New Haven, CT11/04/2016 River Street Jazz Café, Wilkes-Barre, PA11/10/2016 Pearl Street, Northampton, MA11/11/2016 Brooklyn Bowl, Brooklyn, NY (supporting Papadosio)11/16/2016 Aisle 5, Atlanta, GA11/17/2016 Asheville Music Hall, Asheville, NC11/18/2016 The Music Farm, Columbia, SC (supporting Papadosio)11/19/2016 The Music Farm, Charleston, SC (supporting Papadosio)12/01/2016 Ardmore Music Hall, Ardmore, PA12/02/2016 Baltimore Soundstage, Baltimore, MD (supporting TAUK)12/03/2016 Chameleon Club, Lancaster, PA (supporting TAUK)12/07/2016 The Westcott Theater, Syracuse, NY (supporting TAUK)12/08/2016 Nectar’s, Burlington, VT12/09/2016 ONCE Ballroom, Boston, MA12/10/2016 Strange Brew Pub, Norwich, CT12/31/2016 Madison Theater, Covington, KYlast_img read more

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Holy Shit You Guys, Did You See The Cast For The New Lion King Remake?!

first_imgWhile we all grow up in different places with different backgrounds, different living situations, different beliefs, and so on, there is one thing that almost everyone’s childhood had in common: Disney movies. We all watched them, sand along to them, probably had a lunchbox with one of their characters on it at some point in time. Those movies are classics, so when Disney began an extensive campaign of live-action remakes, many people were skeptical. However, so far the films have been great: The technologically groundbreaking 2016 The Jungle Book remake directed by Jon Favreau was a worldwide smash, earning close to $1B worldwide, and this year’s live-action Beauty and the Beast became the highest-grossing live-action musical of all time within ten days of its theatrical release.With the strength of its cast, the proven track record of its director, its beloved story and characters and, of course, the unforgettable soundtrack written by Elton John, Tim Rice, Hans Zimmer, and more, the new live-action remake of The Lion King is shaping up to be a sure-fire classic in its own right.The new Lion King is set to open July 19, 2019. Until then, listen back to the original movie soundtrack and imagine these new voices in the mix. Sounds pretty fantastic to us… In a post on Disney‘s Twitter account yesterday evening, the entertainment giant revealed the full cast for their upcoming live-action remake of 1994 animated musical classic The Lion King–and we couldn’t be more excited about it. Donald Glover (aka Childish Gambino) will play the lead role of Simba, with Beyoncé starring alongside him as Nala. The legendary James Earl Jones will reprise his role as Mufasa from the original film, while Academy Award nominee Whiwetel Ejiofor will play the nefarious Scar and the decorated Alfre Woodard will play Simba’s mother, Sarabi……And that’s just the leads. The rest of the supporting cast is equally star-studded, with comedian and late night host John Oliver playing pessimistic toucan Zazu, South African actor/playwright John Kani voicing the wise Rafiki, and a sure-to-be-hilarous pairing of comedic favorites Seth Rogen and Billy Eichner as Timon and Pumba. Scar’s cackling hyena cronies will be played by multi-talented comedians Eric André and Keegan-Michael Key as well as Ugandan-German actress Florence Kasumba, best known for playing Ayo in the Marvel cinematic canon. Child actors JD McCrary and Shahadi Wright Joseph will play young Simba and young Nala.last_img read more

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Phil Lesh & The Terrapin Family Band Work Led Zeppelin’s “Whole Lotta Love” Inside “St. Stephen” In Philly [Watch]

first_imgOn Sunday, following a busy week of New York shows, Phil Lesh capped his east coast run with The Terrapin Family Band at Philadelphia, PA’s The Fillmore. Billed as “Unbroken Train” the evening included performances by Twiddle and Midnight North in addition to Phil and the Terrapin Family Band.Phil and company once again drew from the Grateful Dead repertoire and beyond for their Philadelphia performance. The highlight of the evening, however, came during the middle of the set, when the band started in on “St. Stephen”. After getting through the body of the composition and into improvisational territory, the band steered into a cover of Led Zeppelin classic “Whole Lotta Love” with Alex Koford (who spent most of this run on drums but moved to guitar for the Philadelphia show) on vocals. From there, the band flirted with the Allman Brothers Band‘s “Mountain Jam” before returning to the “St. Stephen” theme to finish out the segment.You can watch fan-shot footage from Sunday’s Phil Lesh & The Terrapin Family Band set below, including a full video of the “St. Stephen”/”Whole Lotta Love” sandwich:Phil Lesh & The Terrapin Family Band – ” St. Stephen” > “Whole Lotta Love” [Led Zeppelin cover, crowd-shot][Video: super vince]Phil Lesh & The Terrapin Family Band – “Stella Blue”[Video: super vince]Phil Lesh & The Terrapin Family Band – “Werewolves of London” [Warren Zevon cover][Video: super vince]Setlist: Phil Lesh & The Terrapin Family Band | The Fillmore Philadelphia | Philadelphia, PA | 9/9/18 Set: Rumble, Mason’s Children, China Cat Sunflower, Mr. Charlie, Tennessee Jed, Mississippi Half-Step Uptown Toodeloo, The Music Never Stopped, St. Stephen > Whole Lotta Love > St. Stephen, Stella Blue, Help On The Way > River Song > Slipknot! > Franklin’s TowerEncore: Werewolves of Londonlast_img read more

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Faculty Council meeting — April 25, 2018

first_imgOn April 25 the members of the Faculty Council approved preliminary versions of “Courses of Instruction” for 2018–19 and of the University Extension School courses for 2018–19.  They also heard presentations on the MIT MicroMasters program and on Harvard’s expansion in Allston.The last regular meeting of the Faculty will be on May 1.last_img

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A crisper CRISPR

first_img Genome editing with precision Related Radcliffe symposium examines the rapid advances brought by CRISPR Prime editing system offers wide range of versatility in human cells, correcting disease-causing genetic variations Using a previous invention, phage-assisted continuous evolution (PACE), Liu and his team forced SpCas9 to evolve quickly, creating many new generations of the protein in about a week (without PACE, the process takes months or years). Their goal was to produce new SpCas9 proteins that had all the talents of their mom protein but greater versatility. Only proteins capable of recognizing PAM sequences without a G survived the Darwinian selection.“Out came these three families of SpCas9 variants,” Liu said. Collectively, they can direct both cytosine and adenine base editors and park at almost any NR, where R is either an A or a G, giving them access to roughly half of DNA sites. With base editors able to reach across a five-base window to perform edits, the likelihood of a five-base window without an A or G is just 5 percent. “Ninety-five percent of pathogenic point mutations that we know of have an NR PAM in the right place to support base editing,” Liu said. This means base editors can now reach and correct up to 95 percent of point mutations that cause disease.For example, the difficulty of accessing the base mutation that causes most cases of sickle cell anemia had hampered efforts to treat it. “By bad luck, it doesn’t have an NGG in the right place for SpCas9 base editing directly on the sickle cell mutation,” Liu said. “As a result, it’s [been] challenging to use published base editors to go after that site.“And sure enough, using one of the evolved SpCas9 variants that can park at a CACC PAM, we can now base edit this mutation quite efficiently.” Not too long ago, CRISPR was a cryptic acronym — or, to some ears, a drawer to keep lettuce fresh. Today, CRISPR Cas9, the most popular form of the powerful gene-editing technology, is widely used to accelerate experiments, grow pesticide-resistant crops, and design drugs to treat life-threatening genetic diseases like sickle cell anemia.But CRISPR is not perfect. Base editors (think of them as gene-editing pencils) can rewrite individual DNA letters. They home in on specific areas of DNA and swap out certain bases — A, C, T, or G — for others. But after the swap, base editors—like the cytosine base editor that converts C•G to T•A — perform unwanted off-target edits. Until now, even the best CRISPR tool, SpCas9, could only bind to about one in 16 locations along DNA, leaving many genetic mutations out of reach.Now, in two papers published in Nature Biotechnology, researchers at Harvard University, the Broad Institute, and the Howard Hughes Medical Institute have invented new CRISPR tools that address both issues. The first paper describes newly designed cytosine base editors that reduce an elusive type of off-target editing by 10- to 100-fold, making new variants that are especially promising for treating human disease. The second describes a new generation of all-star CRISPR-Cas9 proteins the team evolved that are capable of targeting a much larger fraction of pathogenic mutations, including the one responsible for sickle cell anemia, which was prohibitively difficult to access with previous CRISPR methods.“Since the era of human genome editing is in its fragile beginnings, it’s important that we do everything we can to minimize the risk of any adverse effects when we start to introduce these into people,” said David Liu, the lead author on the papers. “Minimizing this kind of elusive off-target editing is an important step toward achieving that goal.”Reduced off-target editingLiu, Richard Merkin Professor, vice chair of the faculty, and director of the Merkin Institute of Transformative Technologies in Healthcare at the Broad Institute of MIT and Harvard, set out with his team to pinpoint those troubling and erratic CRISPR-independent off-target edits.“That type of off-target editing can occur at random locations in the genome,” said Liu. “When you run the experiment 10 times, you get 10 different answers. That makes it so challenging to study.”,One way to detect CRISPR-independent edits is to sequence the entire genome many times. But such experiments are time-consuming and expensive — tens of thousands of dollars. Instead, Liu and his team designed five new tests that avoid whole-genome sequencing and are both fast and cheap. In one, they sent in a different CRISPR protein to hold the strands of a DNA double helix open at six different locations in the human genome. Base editors strongly prefer to edit single-stranded DNA, so the open strands attract any misbehaving base editors. “By holding the strands open, this assay invites a cytosine base editor to come in and edit in the opened DNA if it’s prone to do so,” Liu said.Then Liu and his team simply searched for base edits in the six open DNA strands. In their first study, they sequenced the whole genome to verify their assays matched the results of the slower and expensive, but proven, method — and they did.Next, Liu tested all 14 major types of cytosine base editor to determine which produced fewer off-target edits. The variant YE1 won: “Even if we held a bunch of DNA loops open enticingly for it to edit, it wouldn’t bite,” Liu said. Since YE1 had a smaller reach than other variants — when parked on DNA, it could only edit the three closest bases — he and his team engineered the tool to reach farther, across five bases. The result is a more precise, selective and versatile suite of base editors. More ground to coverCRISPR has another hurdle to overcome: its limited ability to access the entire human genome. “You can’t actually park Cas9 anywhere in the genome,” Liu said. “You can only park it in places that have a small constant sequence of DNA, called a PAM.”Until now, the most common PAM was NGG, where “N” is any base. But two consecutive Gs only occur in about one in 16 places in the genome. “One out of 16 is bad odds,” Liu said, before calculating the exact probability — 6.25 percent — in a couple of seconds.In 2018, Liu and his lab evolved variants of Cas9 that could recognize some DNA sequences with one G, expanding CRISPR’s reach to one in four. “But among the untrodden territories of SpCas9 are PAM ‘deserts’ that don’t have any Gs,” he said. “Since the era of human genome editing is in its fragile beginnings, it’s important that we do everything we can to minimize the risk of any adverse effects when we start to introduce these into people.” — David Liu Power and pitfalls of gene editing CRISPR enzyme programmed to kill viruses in human cells Researchers harness Cas13 as an antiviral agent and diagnostic tool for RNA-based viruseslast_img read more

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NVMe and I/O Topologies for Dell EMC Intel and AMD PowerEdge Servers

first_imgIf you are a server user considering Non-Volatile Memory Express (NVMe) storage for your infrastructure, then you are seeking to invest in top-of-the-line performance. Leveraging a PCIe interface improves the data delivery path and simplifies software stacks, resulting in a significant latency reduction and bandwidth increase for your storage data transfer transactions.PowerEdge rack servers have unique configurations that are designed for specific value propositions, such as bandwidth, capacity or I/O availability. At times it can be a challenge to determine which configuration is best suited for your intended purpose!We at Dell EMC would like to simplify this process by providing the value propositions for each of our PowerEdge rack configurations; to help our customers choose the right configuration for their objectives. With this, we have also provided detailed illustrations of NVMe and system I/O topologies, so that customers can easily route and connect their best hardware configurations, and optimally design and configure customer software solutions and workloads.We can first look at one of our Intel-based rack servers, the R740xd. There are two suggested NVMe and I/O configurations that have unique value propositions:PowerEdge R740xd with x12 NVMe drives (Maximized Bandwidth)Figure 1: PowerEdge R740xd CPU mapping with twelve NVMe drives and twelve SAS drivesThis 2U R740xd configuration supports twenty-four NVMe drives. The NVMe drives are connected through PCIe switches, which allows the system to overprovision PCIe lanes to more NVMe drives while persevering I/O slots, therefore enabling low latency CPU access to twelve devices per CPU. Performance can easily be scaled for various dense workloads, such as big data analytics. This configuration appeals to customers wanting to consolidate Storage media to NVMe (from SAS/SATA). Customers requiring large capacity with the low latency of NVMe will benefit from this configuration, with up to 24 NVMe drives available for population.PowerEdge R740xd with x24 NVMe drives (Maximized Capacity)Figure 2: PowerEdge R740xd CPU mapping with twenty-four NVMe drivesThis 2U R740xd configuration supports twenty-four NVMe drives. The NVMe drives are connected through PCIe switches, which allows the system to overprovision PCIe lanes to more NVMe drives while persevering I/O slots, therefore enabling low latency CPU access to twelve devices per CPU. Performance can easily be scaled for various dense workloads, such as big data analytics. This configuration appeals to customers wanting to consolidate Storage media to NVMe (from SAS/SATA). Customers requiring large capacity with the low latency of NVMe will benefit from this configuration, with up to 24 NVMe drives available for population.Next, we can look at one of our AMD-based rack servers, the R7425. There are two suggested NVMe and I/O configurations that have unique value propositions:PowerEdge R7425 with x12 NVMe drives (Maximized Bandwidth)Figure 3: PowerEdge R7425 CPU mapping with twelve NVMe drives and twelve SAS drivesThis 2U PowerEdge R7425 configuration supports twelve NVMe drives and twelve SATA/SAS drives. Eight of the NVMe drives are connected directly to the CPU and four of the NVMe drives are connected to CPU1 through a PCIe extender card in I/O slot 3. Customers supporting workloads that demand maximum NVMe and storage performance will need maximum bandwidth to drive the best throughput (GB/s) performance connect to the devices.PowerEdge R7425 with x24 NVMe drives (Maximized Capacity)Figure 4: PowerEdge R7425 CPU mapping with twenty-four NVMe drivesThis 2U PowerEdge R7425 configuration supports twenty-four NVMe drives. Two PCIe switches are included, which allows the system to overprovision PCIe lanes to more NVMe drives while persevering I/O slots, which are then connected directly to the CPU. This configuration maximizes NVMe capacity and reserves slot 3 for additional I/O functionality but has a lower overall bandwidth. This configuration appeals to customers wanting to consolidate storage media to NVMe from SAS/SATA. Customers requiring large capacity with the low latency of NVMe will benefit from this configuration, with up to 24 NVMe drives available for population.Each PowerEdge server sub-group has a unique interconnect topology with various NVMe configurations to consider for implementation. To achieve your data center goals with your NVMe investments, it is critical to understand your NVMe topology, as well as why it is the best option from a value prop point of view.For the full list both Intel-based and AMD-based PowerEdge rack server NVMe and I/O topology illustrations, as well as explanations for each configurations value prop, please view the full NVMe and I/O Topologies Whitepaper now.last_img read more

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Watch a Sneak Peek of Incoming Chicago Star Rumer Willis as Roxie

first_img Related Shows from $49.50 Chicago Rumer Willis will soon razzle dazzle ’em in Chicago and we have our first sneak peek of how she’ll look as Roxie Hart! The Dancing with the Stars winner, who will be making her Broadway debut as her Dad Bruce Wills prepares for his in Misery, has a family, she tells ET, that’s all about “consistency.” Helpful, since over the past few days they haven’t had the easiest of times. Check out the video below and then Rumer raking in the chips at the Ambassador Theatre from August 18. View Commentslast_img read more

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2002 Vermont SBA Small Business Person of the Year

first_imgVermont Business Magazine presents the 2002 Vermont SBA Small Business Person of the Year Awards to be held Wednesday, June 12, 2002, from 4:00pm to 7:00pm on the Green at Vermont College of Union Institute & University in Montpelier. The Vermont District Office of the U.S. Small Business Administration announced the winner of the Small Business Person Award and various Advocacy Awards.The SMALL BUSINESS PERSON OF THE YEAR winner is: Clint “Jito” Coleman, President Northern Power Systems, Waitsfield, VT.A volunteer committee of small business professionals have contributed to the management of the event They are: John Boutin, Publisher, Vermont Business Magazine Sybil Chicoine, Director, Coordinated State Marketing, State of Vermont Mary Collins, Special Projects Coordinator & Web Marketing Development, Vermont Business Magazine Paula Cope, President, Cope & Associates, Inc. Albert Hall III, Economic Development Specialist, Vermont District Office U.S. SBA Cathy Herlihy, District Manager, Vermont Small Business Development Center Norman James, Vice President of Programs, Vermont State Chamber of Commerce Paul Lapotosky, General Manager, Farrell Distributing Corporation Cindy Morgan, Marketing Director, New England Federal Credit Union Cathy Printon, Dean of Students, Goddard College.The Vermont SBA honors individuals and small businesses with the Small Business Person of the Year Award, Entrepreneurial Success, Young Entrepreneur, Home-Based Business, Small Business Exporter, Small Business Journalist and various advocacy awards including Accountant, Financial Services, Minority Small Business, Veteran and Women in Business Advocate.Previous Vermont SBA winners include Susan Dollenmaier of Anichini, Inc.; Edward Kiniry, Tubbs Snowshoe Company; and David Allard, Lyndon Furniture. National winners from Vermont include R. William Hazelett, Hazelett Strip-Casting Corp., National Small Business Exporter of the Year, 2001, and Ben Cohen & Jerry Greenfield, Ben & Jerry’s Homemade, Inc., National Small Business Persons of the Year, 1988.For information about the SBA Small Business Person of the Year Award, contact Al Hall, Economic Development Specialist, Vermont District Office, U.S. Small Business Administration at 802.828.4422, ext. 207. For information about sponsoring and participating in the June 2002, awards event, contact Mary Collins, Special Projects Coordinator at Vermont Business Magazine at 802.863.8038.last_img read more

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Tata Deal Registers as ‘Largest Transaction in the Renewables Space in India’

first_img FacebookTwitterLinkedInEmailPrint分享Vibhuti Agarwal for the Wall Street Journal:India’s Tata Power Co. said it agreed to acquire renewable-energy company Welspun Renewables Energy Pvt. Ltd. in a deal with an enterprise value of 92.49 billion rupees ($1.38 billion).Tata Power Renewable Energy Ltd., the renewables unit of Tata Power, signed an agreement to acquire Welspun Energy’s subsidiary in “the largest transaction in [the] renewables space in India,” Tata Power said in a statement to the stock exchange in Mumbai on Monday.The companies didn’t reveal how much Tata Power Renewable Energy had agreed to pay. Tata Power—the nation’s largest private power-utility company by generation capacity—said the acquisition was being made at an enterprise value of 92.49 billion rupees, subject to closing adjustments. Enterprise value usually comprises the company’s total assets, debt and any cash on its books.Welspun Renewables, part of the Welspun Group, has about 1,140 megawatts of solar and wind power assets across 10 Indian states. Of that, about 990 megawatts is in solar projects and about 150 megawatts is in wind projects.Once the transaction is completed, Tata Power Renewable Energy will own capacity of 2,300 megawatts, “making it the largest renewable power company” in the country.Tata Power Renewable Energy currently operates 294 megawatts of renewable power capacity and about 400 megawatts worth of solar and wind projects that are soon to be completed. Another about 500 megawatts of renewable assets are being carved out of Tata Power into the firm through a court process, the statement said.The company is aiming to double its total generation capacity across thermal, renewable and hydropower to 18,000 megawatts by 2022.Indian Prime Minister Narendra Modi wants to ramp up the country’s wind-power capacity to 60 gigawatts by 2022 from nearly 30 gigawatts. The government has also set a target of installing 100 gigawatts of solar power by 2022, an ambitious target, given that the existing solar capacity is 6.9 gigawatts.Full article ($): India’s Tata Power Buys Welspun Renewables Tata Deal Registers as ‘Largest Transaction in the Renewables Space in India’ Madeleine Cuff for Business Green:In related news, late last week the Indian Energy Ministry announced plans to cancel four coal-fired power stations. The decision to cancel the proposed plants – which had a combined capacity of 16GW – was taken following community resistance and weakening demand growth thanks to improvements in energy efficiency. Commenting on the announcement, Tim Buckley, director of energy finance studies at the Institute for Energy Economics and Financial Analysis, said it is a sign of the dramatic shift underway in India’s energy markets. “This is yet another major policy shift underscoring how seriously India is working to transform, modernise and diversify its electricity sector away from coal,” he said.As part of its climate change strategy India plans to cut coal use and boost its power generation from renewables from 12 per cent today to 40 per cent by 2030. To achieve this, Prime Minister Narendra Modi plans to double India’s wind power capacity to 60GW by 2022, and install 100GW of solar power by the same date.Full article: Tata Power aims to fuel India’s renewables revolution with acquisition of Welspun Renewableslast_img read more

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Why the world will NOT end when EMV chargeback liability shifts

first_imgWe are just one month away from the EMV chargeback liability shift, and many card issuing banks and credit unions are rushing to get the new chip technology in the hands of consumers.  Retailers in the US are growing nervous about upgrading their POS terminals. Consumers are annoyed by all the new credit cards they’re receiving in the mail, and confused about what to do with the chip cards when they finally find themselves at an EMV-capable machine. Retail clerks are learning how to run checkouts using the new chip cards, finding themselves in the unwanted position of educating irritated consumers.  Despite all these hiccups in the adoption of EMV technology and the hype surrounding its rollout, I have news for you: much like the hype leading up to Y2K, the world will NOT end in October.First, at the beginning of 2015, less than a third of credit cards were chip-enabled, and even fewer debit cards carried the chip. By the end of 2015, it’s estimated that 70% of credit cards will be chip-enabled. That’s an impressive projected jump, but debit cards are estimated to still be lagging at only 40%. So while great strides are being made to upgrade US cards, not everyone will have EMV cards by October as some news reports would have you believe.Second, according to CNBC, only slightly over 40% of US retailers have even committed to EMV. In the end, it’s these merchants who have the biggest exposure to risk by not adopting EMV, since chargeback liability will now be on their shoulders should they resist the move.  So why not a bigger push to upgrade terminals ASAP?  Because retailers aren’t falling for all the hype.  Many have realized that they’re not at risk, or are at very little risk of chargebacks, and have elected not to upgrade at this time. continue reading » 26SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblrlast_img read more

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